The muscle relaxer Botox has now been shown to positively affect the skin as well. "Botox definitely clears up acne," says Anil Shah M.D. The Chicago plastic surgeon is one of the only doctors worldwide using Botox in an entirely new way. He injects the muscle relaxer directly into the skin to eliminate large pores, oil production, and acne breakouts. Acne is caused when the skin's sebaceous glands release too much oil, or sebum, into the skin's pores.