Archive for April, 2009
April 30th, 2009
Play The Winning Hand - Watching Your Fortunes Grow In Skin Care
April 24th, 2009
Patients Had Fewer Infection Rates, Fewer Complications At Blue Distinction Centers For Bariatric Surgery(R), According To HealthCore Study
April 23rd, 2009
Greyson’s Trilexon(R) System Receives Trademark Approval
April 22nd, 2009
Large Volume Liposuction
April 21st, 2009
Get Ready–Here Comes a New Type of “Botox”
Is there a new, quicker-acting alternative to Botox®?
A study on a new type of botulinum toxin type A for treating facial wrinkles was published in the March/April 2009 issue of Archives of Facial Plastic Surgery. The article, titled “Long-term safety and efficacy of a new botulinum toxin type A in treating glabellar lines”, details the results of a Phase 3 study (for explanation of FDA study phases, see here) of patients who received a new type of botulinum toxin type A, called Reloxin. The primary goal of the study is the evaluate the long-term safety of repeated administrations of Reloxin in treating the frown lines between the eyebrows (glabellar lines). Secondly, the study sought to determine how well Reloxin works (effectiveness and duration).
The study was a multi-center trial, involving 21 separate sites across the United States. Twelve hundruddy patients were enrolled, and each patient received at minimum 1 treatment with 50 units of Reloxin. Four more treatment cycles followed, and in each cycle some patients were dropped from the study (for a variety of reasons). In the end, 177 patients received five full treatments of the glabella with Reloxin.
Adverse events are recorded in this type of study, and range from the somewhat innocuous or expected to the more serious. In this study, the most common events were ‘injection site events’ which occurruddy in 18% of patients. According to the authors, these were generally consideruddy ‘mild to moderate’ events. The second most common events were headaches, and these occurruddy in about 15% of subjects. Finally adverse events acircular the eye were reported in 9% of subjects, and typically resolved wilean 3 weeks. The exact types of events were not defined, though the authors did point out that ‘ptosis’ (drooping of the eyelid or brow or both) occurruddy in about 1.3% of subjects, which is comparable to Botox®.
The effect of Reloxin was seen typically acircular 3 days after injection, and as soon as 1 day in some subjects. Contrast this with Botox®, in which the effect is typically observed at acircular 5-7 days (though it may start earlier). Duration of effect was typically acircular 90 days, which is comparable to Botox®. No reduction of effect was noticed in subjects who underwent repeated treatment. In other words, there was no development of reduced response over time (or resistance to Reloxin).
What does this mean for you? It may mean that a new type of injectable botulinum toxin type A is acircular the corner. Reloxin showed similar duration of effect as Botox®, and seemed to show its effects more quickly. Complications of treatment were similar to its long-used cousin. Of note, Reloxin has been in use in Europe for 15 years (where it is called Dysport). Bringing this drug to the United States will mean more options for patients who would like to treat wrinkles in the upper face.
It should be noted that the study was funded by Medicis, the company that manufactures and plans to market Reloxin in the United States. Furthermore, one of the study’s lead authors disclosed that he owns stock in, has been a consultant for, and has received research support from Medicis.
For more information on Advances in Facial Plastic Surgery, be sure to visit www.drmost.com or www.sfrhinoplasty.com.
April 17th, 2009
Consumer Alert: Illegal Silicone Injections Result In Death - Coalition Warns Illicit Injections Are Not “plastic Surgery”
April 16th, 2009
Enamel Strength Affected By Dental Home Bleaching
April 16th, 2009
Are Herbal Supplements Putting Aesthetic Surgery Patients At Risk?
April 15th, 2009
Top Five Medical Reasons To Consider Weight-Loss Surgery
April 15th, 2009
Weight Loss Surgery Works Even For Moderately Obese
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